The Lions were led in scoring by senior forward Dominique Mosley with 13 points. Alexis Fitzpatrick added 11 while Nicole Hartzog chipped in 10 points.
Fort Hays limited the Lions to only 32.7% from the field in the first half and 23.1% in the second half.
With the loss, Southern is unlikely to move into the top eight in the regional rankings.
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